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ⓘ GDP-mannose 6-dehydrogenase. In enzymology, a GDP-mannose 6-dehydrogenase is an enzyme that catalyzes the chemical reaction GDP-D-mannose + 2 NAD + + H 2 O ⇌ {\ ..



                                     

ⓘ GDP-mannose 6-dehydrogenase

In enzymology, a GDP-mannose 6-dehydrogenase is an enzyme that catalyzes the chemical reaction

GDP-D-mannose + 2 NAD + + H 2 O ⇌ {\displaystyle \rightleftharpoons } GDP-D-mannuronate + 2 NADH + 2 H +

The 3 substrates of this enzyme are GDP-D-mannose, NAD +, and H 2 O, whereas its 3 products are GDP-D-mannuronate, NADH, and H +.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is GDP-D-mannose:NAD + 6-oxidoreductase. Other names in common use include guanosine diphosphomannose dehydrogenase, GDP-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase, and guanosine diphospho-D-mannose dehydrogenase. This enzyme participates in fructose and mannose metabolism.

This protein may use the morpheein model of allosteric regulation.

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