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ⓘ Erythronolide synthase. In enzymology, an erythronolide synthase is an enzyme that catalyzes the chemical reaction 6 malonyl-CoA + propanoyl-CoA ⇌ {\displaystyl ..



                                     

ⓘ Erythronolide synthase

In enzymology, an erythronolide synthase is an enzyme that catalyzes the chemical reaction

6 malonyl-CoA + propanoyl-CoA ⇌ {\displaystyle \rightleftharpoons } 7 CoA + 6-deoxyerythronolide b

Thus, the two substrates of this enzyme are malonyl-CoA and propanoyl-CoA, whereas its two products are CoA and 6-deoxyerythronolide b.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:propanoyl-CoA malonyltransferase cyclizing. Other names in common use include erythronolide condensing enzyme, and malonyl-CoA:propionyl-CoA malonyltransferase cyclizing. This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.

                                     

1. Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1KEZ, 1MO2, 1PZQ, 1PZR, 2HG4, 2JU1, 2JU2, and 2QO3.

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