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ⓘ Gamma-glutamylcyclotransferase. In enzymology, a gamma-glutamylcyclotransferase is an enzyme that catalyzes the chemical reaction 5-L-glutamyl-L-amino acid ⇌ {\ ..



                                     

ⓘ Gamma-glutamylcyclotransferase

In enzymology, a gamma-glutamylcyclotransferase is an enzyme that catalyzes the chemical reaction

5-L-glutamyl-L-amino acid ⇌ {\displaystyle \rightleftharpoons } 5-oxoproline + L-amino acid

Hence, this enzyme has one substrate, 5-L-glutamyl-L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is 5-L-glutamyl-L-amino-acid 5-glutamyltransferase cyclizing. Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

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